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1

Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs

Donna A. Volpe, Grainne A. McMahon Tobin, R. Daniel Mellon, Aspandiar G. Katki, Robert J. Parker, Thomas Colatsky, Timothy J. Kropp, S. Leigh Verbois

Journal:

Regulatory Toxicology and Pharmacology

Year:

2011

Language:

english

File:

PDF, 432 KB

english, 2011

2

More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems

Hartman, Neil R., Mao, Jinzhe J., Zhou, Hongfei, Boyne, Michael T., Wasserman, Adam M., Taylor, Kellie, Racoosin, Judith A., Patel, Vikram, Colatsky, Thomas

Journal:

Regulatory Toxicology and Pharmacology

Year:

2014

Language:

english

File:

PDF, 729 KB

english, 2014

3

Electrical properties of canine subendocardial Purkinje fibers surviving in 1-day-old experimental myocardial infarction

Argentieri, T. M., Frame, L. H., Colatsky, T. J.

Journal:

Circulation Research

Year:

1990

Language:

english

File:

PDF, 2.59 MB

english, 1990

4

Influence of transmural repolarization gradients on the electrophysiology and pharmacology of ventricular myocardium. Cellular basis for the Brugada and long-QT syndromes

Antzelevitch, C., Nesterenko, V. V., Muzikant, A. L., Rice, J. J., Chen, G., Colatsky, T.

Journal:

Philosophical Transactions Mathematical Physical & Engineering Sciences

Year:

2001

Language:

english

File:

PDF, 1.67 MB

english, 2001

5

Potassium channels as targets for antiarrhythmic drug action

Dr. T. J. Colatsky, C. H. Follmer

Journal:

Drug Development Research

Year:

1990

Language:

english

File:

PDF, 809 KB

english, 1990

6

Potassium channel blockers as antiarrhythmic drugs

Thomas J. Colatsky, Thomas M. Argentieri

Journal:

Drug Development Research

Year:

1994

Language:

english

File:

PDF, 1.54 MB

english, 1994

7

N-sulfonamides of benzopyran-related potassium channel openers: Conversion of glyburide insensitive smooth muscle relaxants to potent smooth muscle contractors

R.M. Soll, P.J. Dollings, R.J. McCaully, T.M. Argentieri, N. Lodge, G. Oshiro, T. Colatsky, N.W. Norton, D. Zebick, C. Havens, N. Halaka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 377 KB

english, 1994

8

3-hydroxy-3-cyclobutene-1,2-dione: Application of novel carboxylic acid bioisostere to an in-vivo active non-tetrazole angiotensin-II antagonist

R.M. Soll, W.A. Kinney, J. Primeau, L. Garrick, R.J. McCaully, T. Colatsky, G. Oshiro, C.H. Park, D. Hartupee, V. White, J. McCallum, A. Russo, J. Dinish, A. Wojdan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 267 KB

english, 1993

9

Metabolomics data and the biomarker qualification process

Richard D. Beger, Thomas Colatsky

Journal:

Year:

2012

Language:

english

File:

PDF, 170 KB

english, 2012

10

K+ Channel Blockers and Activators in Cardiac Arrhythmias

Thomas J. Colatsky, Christopher H. Follmer

Journal:

Cardiovascular Therapeutics

Year:

1989

Language:

english

File:

PDF, 706 KB

english, 1989

11

Sodium channels in rabbit cardiac Purkinje fibres

COLATSKY, T. J., TSIEN, R. W.

Journal:

Year:

1979

File:

PDF, 378 KB

1979

12

Efficacy of the antidepressant iprindole against experimental arrhythmias

Thomas J. Colatsky, John D. McCallum, Karen Nocella, Nancy K. Jurkiewicz, Lesa B. Bird

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 689 KB

english, 1986

13

Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs

Walter Spinelli, Christopher Follmer, Roderick Parsons, Thomas Colatsky

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 707 KB

english, 1990

14

Physico-chemical correlates of resting Na+ channel block in cardiac myocytes studied in a series of benzenesulfonamide analogues

Christopher H. Follmer, Catherine A. Cullinan, Cynthia Pirozzi, Thomas J. Colatsky

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1989

Language:

english

File:

PDF, 107 KB

english, 1989

15

Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats

Karol L. Thompson, Jun Zhang, Sharron Stewart, Barry A. Rosenzweig, Katherine Shea, Daniel Mans, Thomas Colatsky

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 429 KB

english, 2012

16

Ion Channels: Too Complex for Rational Drug Design?

Steve A.N Goldstein, Thomas J Colatsky

Journal:

Year:

1996

Language:

english

File:

PDF, 90 KB

english, 1996

17

Potentiation of phosphodiesterase inhibitor antithrombotic activity with alpha-2 adrenergic blockade

Jan M. Kitzen, John D. McCallum, Cynthia T. Pirozzi, Thomas J. Colatsky

Journal:

Year:

1991

Language:

english

File:

PDF, 442 KB

english, 1991

18

Long QT syndrome patients genetically linked to defective genes on chromosomes 11, 7 and 3 present differential response to changes in heart rate

Silvia G. Priori, Carlo Napolitano, Emanuela H. Locati, Francesco Cantù, Marco Stramba-Badiale, Mark T. Keating, Jeffrey A. Towbin, Thomas J. Colatsky, Ling Sing K. Chen, Peter J. Schwartz

Journal:

Journal of the American College of Cardiology

Year:

1996

Language:

english

File:

PDF, 282 KB

english, 1996

19

Comparative antithrombotic activities of the phosphodiesterase inhibitors pelrinone (AY-26,768), AY-31,390 and milrinone

Diana M. Patelunas, William J. Carmint, Janet Z. Willis, Thomas J. Colatsky, Richard L. Fenichel

Journal:

Thrombosis Research

Year:

1991

Language:

english

File:

PDF, 982 KB

english, 1991

20

(Q)SAR Modeling and Safety Assessment in Regulatory Review

Kruhlak, N L, Benz, R D, Zhou, H, Colatsky, T J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 112 KB

english, 2012

21

EADB: An Estrogenic Activity Database for Assessing Potential Endocrine Activity

Shen, J., Xu, L., Fang, H., Richard, A. M., Bray, J. D., Judson, R. S., Zhou, G., Colatsky, T. J., Aungst, J. L., Teng, C., Harris, S. C., Ge, W., Dai, S. Y., Su, Z., Jacobs, A. C., Harrouk, W., Perki

Journal:

Toxicological Sciences

Year:

2013

Language:

english

File:

PDF, 12.43 MB

english, 2013

22

A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification

Noble, Denis, Colatsky, Thomas J

Journal:

Expert Opinion on Therapeutic Targets

Year:

2000

Language:

english

File:

PDF, 296 KB

english, 2000

23

Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1

Rouse, R., Min, M., Francke, S., Mog, S., Zhang, J., Shea, K., Stewart, S., Colatsky, T.

Journal:

Toxicologic Pathology

Year:

2015

Language:

english

File:

PDF, 593 KB

english, 2015

24

Comparison of the Diagnostic Accuracy of Di-22:6-Bis(monoacylglycerol)Phosphate and Other Urinary Phospholipids for Drug-Induced Phospholipidosis or Tissue Injury in the Rat

Thompson, K. L., Haskins, K., Rosenzweig, B. A., Stewart, S., Zhang, J., Peters, D., Knapton, A., Rouse, R., Mans, D., Colatsky, T.

Journal:

International Journal of Toxicology

Year:

2012

Language:

english

File:

PDF, 434 KB

english, 2012

25

Block of delayed rectifier potassium current, IK, by flecainide and E- 4031 in cat ventricular myocytes

Follmer, C. H., Colatsky, T. J.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.21 MB

english, 1990

26

Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. An effect on steady state sodium currents?

Colatsky, T. J.

Journal:

Circulation Research

Year:

1982

Language:

english

File:

PDF, 1.03 MB

english, 1982

27

Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury

Zhang, J., DeFelice, A. F., Hanig, J. P., Colatsky, T.

Journal:

Toxicologic Pathology

Year:

2010

Language:

english

File:

PDF, 431 KB

english, 2010

28

Controlling Cardiac Arrhythmias: New Drugs in Development and Insights From Molecular Biology

Colatsky, T. J.

Journal:

Journal of Cardiovascular Pharmacology and Therapeutics

Year:

1998

Language:

english

File:

PDF, 418 KB

english, 1998

29

Inhibition of Cardiac Delayed Rectifier K+ Current by Overexpression of the Long-QT Syndrome HERG G628S Mutation in Transgenic Mice

Babij, P., Askew, G. R., Nieuwenhuijsen, B., Su, C.-M., Bridal, T. R., Jow, B., Argentieri, T. M., Kulik, J., DeGennaro, L. J., Spinelli, W., Colatsky, T. J.

Journal:

Circulation Research

Year:

1998

Language:

english

File:

PDF, 609 KB

english, 1998

30

Effects of external calcium, calcium channel-blocking agents, and stimulation frequency on cycle length-dependent changes in canine cardiac action potential duration

Colatsky, T. J., Hogan, P. M.

Journal:

Circulation Research

Year:

1980

Language:

english

File:

PDF, 1.19 MB

english, 1980

31

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Le

Journal:

Journal of Biomolecular Screening

Year:

2015

Language:

english

File:

PDF, 851 KB

english, 2015

32

Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock

Follmer, C. H, Cullinan, C. A, Colatsky, T. J

Journal:

Cardiovascular Research

Year:

1992

Language:

english

File:

PDF, 1.57 MB

english, 1992

33

Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres.

Journal:

The Journal of Physiology

Year:

1980

Language:

english

File:

PDF, 2.45 MB

english, 1980

34

Commentaries on the Cardiovascular Controversy by W Spinelli and T J Colatsky

Spinelli, W., Colatsky, T. J

Journal:

Cardiovascular Research

Year:

1994

Language:

english

File:

PDF, 460 KB

english, 1994

35

Electrical properties associated with wide intercellular clefts in rabbit Purkinje fibres.

Colatsky, T J, Tsien, R W

Journal:

The Journal of Physiology

Year:

1979

Language:

english

File:

PDF, 3.01 MB

english, 1979

36

Effects of WAY-123,398, a New Class III Antiarrhythmic Agent, on Cardiac Refractoriness and Ventricular Fibrillation Threshold in Anesthetized Dogs: A Comparison with UK-68798, E-4031, and dl-Sotalol

Spinelli, Walter, Parsons, Roderick W., Colatsky, Thomas J.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1992

File:

PDF, 891 KB

1992

37

Cardiac Electrophysiology of the Antiarrhythmic Agent Recainam (Wy-42,362) in Anesthetized Dogs

Colatsky, T. J., Bird, L. B., Knowles, J. A.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1988

File:

PDF, 692 KB

1988

38

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

Li, Zhihua, Dutta, Sara, Sheng, Jiansong, Tran, Phu N., Wu, Wendy, Colatsky, Thomas

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 729 KB

english, 2016

39

Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes

Spinelli, W., Moubarak, I. F, Parsons, R. W, Colatsky, T. J

Journal:

Cardiovascular Research

Year:

1993

Language:

english

File:

PDF, 1.30 MB

english, 1993

40

The Sicilian Gambit and antiarrhythmic drug development

Journal:

Cardiovascular Research

Year:

1992

Language:

english

File:

PDF, 696 KB

english, 1992

41

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

Colatsky, Thomas, Fermini, Bernard, Gintant, Gary, Pierson, Jennifer B., Sager, Philip, Sekino, Yuko, Strauss, David G., Stockbridge, Norman

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 339 KB

english, 2016

42

Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias

Colatsky, T. J., Follmer, C. H., Starmer, C. F.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.81 MB

english, 1990

43

Cellular Electrophysiology of the New Antiarrhythmic Agent Recainam (Wy-42,362) in Canine Cardiac Purkinje Fibers

Colatsky, T. J., Bird, L. B., Jurkiewicz, N. K., Wendt, R. L.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1987

File:

PDF, 722 KB

1987

44

A Critical Role for Immune System Response in Mediating Anti-influenza Drug Synergies Assessed by Mechanistic Modeling

Li, Z, Zhou, H, Lu, Y, Colatsky, T

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2014

Language:

english

File:

PDF, 803 KB

english, 2014

45

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

Li, Zhihua, Dutta, Sara, Sheng, Jiansong, Tran, Phu N., Wu, Wendy, Chang, Kelly, Mdluli, Thembi, Strauss, David G., Colatsky, Thomas

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2017

Language:

english

File:

PDF, 3.35 MB

english, 2017

46

Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine

Hartman, Neil, Zhou, Hongfei, Mao, Jinzhe, Mans, Daniel, Boyne, Michael, Patel, Vikram, Colatsky, Thomas

Journal:

Year:

2017

Language:

english

File:

PDF, 771 KB

english, 2017

47

Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity

Sheng, Jiansong, Tran, Phu N., Li, Zhihua, Dutta, Sara, Chang, Kelly, Colatsky, Thomas, Wu, Wendy W.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 1.43 MB

english, 2017

48

Potassium Channel Activators Cromakalim and Celikalim (WAY-120,491) Fail to Decrease Myocardial Infarct Size in the Anesthetized Canine

Kitzen, Jan M., McCallum, John D., Harvey, Charlotte, Morin, Mary Ellen, Oshiro, George T., Colatsky, Thomas J.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.72 MB

english, 1992

49

Another layer of ventricular heterogeneity? α1 agonists prolong repolarization in Purkinje fibers but not M-Cells

Journal:

Cardiovascular Research

Year:

1999

Language:

english

File:

PDF, 43 KB

english, 1999

50

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Dutta, Sara, Chang, Kelly C., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Wendy W., Wu, Min, Strauss, David G., Colatsky, Thomas, Li, Zhihua

Journal:

Frontiers in Physiology

Year:

2017

Language:

english

File:

PDF, 2.46 MB

english, 2017

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